Volume 3, Issue 1, June 2019, Page: 1-7
Magnesium Concentration in Asthma Patients in Gaza Strip - Case Control Study
Kholoud Abed El-Fattah Omran, Department of Medical Science, University Collage of Science and Technology, Gaza, Palestine
Yusuf Khaled Elzyyan, Department of Medical Science, University Collage of Science and Technology, Gaza, Palestine
Emad Atef Saqer, Department of Medical Science, University Collage of Science and Technology, Gaza, Palestine
Abed Elraheem Nasrallah Safi, Department of Medical Science, University Collage of Science and Technology, Gaza, Palestine
Received: Oct. 13, 2018;       Accepted: Apr. 22, 2019;       Published: May 10, 2019
DOI: 10.11648/j.jcebe.20190301.11      View  652      Downloads  109
Asthma is a common heterogeneous inflammatory chronic disorder of the airways. It is “defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and in intensity often with variable expiratory airflow limitation can be demonstrated”. According to the World Health Organization, asthma is the most common chronic respiratory disorder among children. Magnesium deficiency is associated with increased contractility of smooth muscle cells. Since contractility of bronchial smooth muscle is important in patients with asthma, magnesium deficiency could negatively influence the clinical condition. On the basis of the critical role of Mg in the regulation of bronchial smooth muscle, studies have shown that intravenous application or inhalation of Mg could alleviate symptoms in asthmatic patient. In the present study which was a case-control study plasma concentration of magnesium in 50 asthma patients (27 male, 23 female) in Gaza strip were measured and compare with 50 healthy non-asthmatic controls (37 male, 13 female). Questionnaire interview was applied. The concentrations of Mg were measured by using spectrophotometer. The mean±SD magnesium level in plasma was 1.52±0.4 mg/dl, 2.02±0.27 mg/dl in cases and control respectively, there was statically significant difference between cases and control (P=0.000). Thirty-nine (78%) of cases had Mg deficiency while seven (14%) of control had Mg deficiency. Seven (14%) of patient had sensitivity to dairy product (P=0.031). Forty-five (90%) of patient had health problems especially frequent inflammation of eyes, nose and throat (P=0.000). There were significant differences between cases and control in family history of disease (P=0.000). The finding of this study demonstrate that asthmatics patient had lower plasma magnesium level compared to healthy controls in Gaza strip.
Asthma, Magnesium, Chronic, Gaza Strip
To cite this article
Kholoud Abed El-Fattah Omran, Yusuf Khaled Elzyyan, Emad Atef Saqer, Abed Elraheem Nasrallah Safi, Magnesium Concentration in Asthma Patients in Gaza Strip - Case Control Study, Journal of Chemical, Environmental and Biological Engineering. Vol. 3, No. 1, 2019, pp. 1-7. doi: 10.11648/j.jcebe.20190301.11
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reddel, H. K., Bateman, E. D., Becker, A., Boulet, L. P., Cruz, A. A., Drazen, J. M.,... & Lemanske, R. F. (2015). A summary of the new GINA strategy: a roadmap to asthma control. European Respiratory Journal, 46 (3), 622-639.
Asthma GI. Global Strategy for Asthma Management and Prevention: GINA; 2018. Available from: http://www.ginasthma.org/. [Last accessed on 2018 Nov 16].
Global Initiative for Asthma, (2008). Global strategy for asthma management and prevention. Available at: www.Ginasthma.org. last accessed, September, 2017.
Elin, R. (1987). Assessment of magnesium status. Clinical chemistry, vol. 33, no. 11.
Seelig, MS. (1981). Magnesium requirements in human nutrition. Magnesium Bull; 3: 26-47.
Mellinghoff, K. & van Lessen, W. (1949). Magnesium-calcium Bilanz bei Inanition. Dtach Arch Kiln Med; 194: 285-93.
Mellinghoff, K. (1949). Magnesium stoffwechsel Storungen bel Inanition. Dtsch Arch Klin Med; 195: 475-80.
Spivey WH., Skobeloff EM. and Levin RM. (1990). Levin RM. Effect of magnesium chloride on rabbit bronchial smooth muscle. Ann Emerg Med; 19 (10): 1107-12.
Bloch, H. Silverman, R. Mancherje, N. Grant, S. Jagminas, L. & Scharf SM. (1995). Intravenous magnesium sulfate as an adjunct in the treatment of acute asthma. Chest; 107 (6): 1576-81.
Hill, J. Micklewright, A. Lewis, S. & Britton, J, (1997). Investigation of the effect of short-term change in dietary magnesium intake in asthma. Eur Respir J; 10 (10): 2225-9.
Ishizaka, K. Tomioka, H. & Ishizaka, T. (1970). Mechanisms of passive sensitization. I. Presence of IgE and IgG molecules on human leukocytes. J Immunol; 105 (6): 1459-67.
Cepelak, I. & Cvorisce, D. (1997). Magnezij. Biochem Med; 7 (34): 93-107.
Hasan M. Gofin R. & Bar-Yishay E. (2009): Urbanization and the Risk of Asthma Among Schoolchildren in the Palestinian Authority, Volume 37, 2000 - Issue 4.
Shaikh, M. N., Malapati, B. R., Gokani, R., Patel, B., & Chatriwala, M. (2016). Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity. Pulmonary Medicine, 2016.‏
Lee, S. H., Song, W. J., Park, H. W., Kim, S. H., Park, H. K., Kim, S. H.,... & Choi, B. W. (2017). Serum micronutrients levels and clinical features of elderly asthmatics. Allergy, Asthma & Respiratory Disease, 5 (4), 223-227.
Ali, A. Bakr, R. Yousif, M. Foad, R. (2015): Assessment of serum magnesium level in patients with bronchial asthma, 4 (13), 27-32.
Weiss, K. B., Gergen, P. J., & Wagener, D. K. (1993). Breathing better or wheezing worse? The changing epidemiolgy of asthma morbidity and mortality. Annual review of public health, 14 (1).
Mannino, D. M., Homa, D. M., Pertowski, C. A., Ashizawa, A., Nixon, L. L., Johnson, C. A.,... & Kang, D. S. (1998). Surveillance for asthma—United States, 1960–1995. MMWr CDC Surveill Summ, 47 (1), 1-27.
Eisner M. (2002): American Journal of Respiratory and Critical Care Medicine; Vol. 165, No. 11.
Torén K. Hermansson BA. (1999): Incidence rate of adult-onset asthma in relation to age, sex, atopy and smoking: a Swedish population-based study of 15813 adults; 3 (3), 192-7.
Nurmatov, U., Devereux, G., & Sheikh, A. (2011). Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis. Journal of Allergy and Clinical Immunology, 127 (3), 724-733.
Edqvist, J., & Hassan, M. (2013). Protein and Energy Intake in Children with Cow’s Milk Protein Allergy: The results of three-day estimated food records in Swedish children 2-11 years of age compared to control group.‏
Liu, T. Valdez, R. Yoon, R. Crocker, R. Moonesinghe, R. & Khoury, M. (2009): The association between family history of asthma and the prevalence of asthma among US adults: National Health and Nutrition Examination Survey, 11, 323–328.
Davoodi, P. Mahesh, D. Holla, A. &Ramachandra, N. (2015): Family history & the risk for adult onset asthma, 141 (3): 361–363.
Oladipo, O. Chukwu, C. Ajala, M. (2003): Plasma magnesium in adult asthmatics at the Lagos University Teaching Hospital, 80- 488–491. Pediatrics Jan, 81 (1) 1-7.
Agin K., Darjani H. (2005). Blood Serum Magnesium Values in Chronic Stable Asthmatic Patients: A Case - Control Study. 4 (13), 27-32.
Wang, J. L. Shaw, N. S. & Kao, M. D. (2007). Magnesium deficiency and its lack of association with asthma in Taiwanese elementary school children. Asia Pacific journal of clinical nutrition, 16 (S2), 579-584.
Valk, H. Kok, P. Struyvenberg, A. van Rijn, H. Haalboom, H. Kreukniet, J. & Lammers, J. (1993): Extracellular and intracellular magnesium concentrations in asthmatic patients; 4 (9), 225-245.
Alamoudi OS., (2001). Electrolyte disturbances in patients with chronic, stable asthma: effect of therapy. Chest.; 120 (2): 431-6.
Britton, J. Pavord, I. Richards, K. Wisniewski, A. Knox, A. Lewis, S. & Tattersfield, A. (1994): Dietary magnesium, lung function, wheezing, and airway hyperreactivity in a random adult population sample.; 344 (8919): 357- 62.
Alamoudi, O. S. (2000). Hypomagnesaemia in chronic, stable asthmatics: prevalence, correlation with severity and hospitalization. European Respiratory Journal, 16 (3), 427-431.
Daliparty, V. M., Manu, M. K., & Mohapatra, A. K. (2018). Serum magnesium levels and its correlation with level of control in patients with asthma: A hospital-based, cross-sectional, prospective study. Lung India: official organ of Indian Chest Society, 35 (5), 407.
Knightly, R., Milan, S. J., Hughes, R., Knopp‐Sihota, J. A., Rowe, B. H., Normansell, R., & Powell, C. (2017). Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database of Systematic Reviews, (11).
Irazuzta, J. E., & Chiriboga, N. (2017). Magnesium sulfate infusion for acute asthma in the emergency department. Jornal de pediatria, 93, 19-25.
Browse journals by subject